Pathology

Psoriasis and Inflammation – key players and Curcumin Involvement

Global Journal of Pathology & Laboratory Medicine
Volume 1, Issue 1, June 2020, Pages: 12-20
Received: Mar. 17, 2020; Accepted: Apr. 17, 2020; Published: Apr. 27, 2020

Authors: Dr. Elena Niculet, Romania

Abstract:   

Introduction:

Psoriasis is a chronic inflammatory disorder with multisystem involvement, affecting body sites such as the skin, joints (most frequent involvement), or entheses and uvea.

Its complex pathogenesis involves T lymphocytes (CD4+, CD8+), dendritic cells and many inflammatory molecules – interleukins or ckemokines: TNF-α, IL-6, IL-17, IL-8, IL-20, IL-23. The cellular and molecular interactions, combined with a genetic susceptibility, determine  keratinocytic responses manifesting as hyperproliferation, with the presence of epidermal and dermal inflammatory infiltrates, which translates on macroscopic examination as erythematous plaques.

Keywords: Inflammation, Psoriasis

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To citation of this article: Elena Niculet, Psoriasis and Inflammation – key players and Curcumin Involvement, Global Journal of Pathology & Laboratory Medicine

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